Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0001516 | biological_process | prostaglandin biosynthetic process |
A | 0004033 | molecular_function | aldo-keto reductase (NADPH) activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0036130 | molecular_function | prostaglandin H2 endoperoxidase reductase activity |
A | 0044281 | biological_process | small molecule metabolic process |
B | 0000166 | molecular_function | nucleotide binding |
B | 0001516 | biological_process | prostaglandin biosynthetic process |
B | 0004033 | molecular_function | aldo-keto reductase (NADPH) activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0036130 | molecular_function | prostaglandin H2 endoperoxidase reductase activity |
B | 0044281 | biological_process | small molecule metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 35 |
Details | BINDING SITE FOR RESIDUE NDP A 301 |
Chain | Residue |
A | GLY23 |
A | GLN171 |
A | TRP197 |
A | SER198 |
A | PRO199 |
A | LEU200 |
A | GLY201 |
A | GLN202 |
A | GLY203 |
A | LEU206 |
A | ILE238 |
A | VAL24 |
A | PRO239 |
A | LYS240 |
A | SER241 |
A | VAL242 |
A | HIS243 |
A | ARG246 |
A | GLU249 |
A | ASN250 |
A | HOH427 |
A | HOH434 |
A | TRP25 |
A | HOH436 |
A | HOH437 |
A | HOH439 |
A | HOH440 |
A | HOH546 |
A | HOH573 |
A | ASP49 |
A | TYR54 |
A | HIS112 |
A | TRP113 |
A | SER149 |
A | ASN150 |
site_id | AC2 |
Number of Residues | 37 |
Details | BINDING SITE FOR RESIDUE NDP B 301 |
Chain | Residue |
B | GLY23 |
B | VAL24 |
B | TRP25 |
B | ASP49 |
B | TYR54 |
B | LYS79 |
B | HIS112 |
B | SER149 |
B | ASN150 |
B | GLN171 |
B | TRP197 |
B | SER198 |
B | PRO199 |
B | LEU200 |
B | GLY201 |
B | GLN202 |
B | GLY203 |
B | LEU206 |
B | ALA223 |
B | ILE238 |
B | PRO239 |
B | LYS240 |
B | SER241 |
B | VAL242 |
B | HIS243 |
B | ARG246 |
B | GLU249 |
B | ASN250 |
B | HOH437 |
B | HOH440 |
B | HOH441 |
B | HOH564 |
B | HOH568 |
B | HOH586 |
B | HOH599 |
B | HOH632 |
B | HOH786 |
Functional Information from PROSITE/UniProt
site_id | PS00062 |
Number of Residues | 18 |
Details | ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. FeqlykekkVRAIGVSNF |
Chain | Residue | Details |
A | PHE134-PHE151 | |
site_id | PS00063 |
Number of Residues | 16 |
Details | ALDOKETO_REDUCTASE_3 Aldo/keto reductase family putative active site signature. IPKSVHreRIeENaDI |
Chain | Residue | Details |
A | ILE238-ILE253 | |
site_id | PS00798 |
Number of Residues | 18 |
Details | ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHIDTAaiyknEesVG |
Chain | Residue | Details |
A | GLY44-GLY61 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor => ECO:0000250 |
Chain | Residue | Details |
A | TYR54 | |
B | TYR54 | |
site_id | SWS_FT_FI2 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | HIS112 | |
A | SER149 | |
A | GLN171 | |
A | TRP197 | |
A | LYS240 | |
A | ARG246 | |
B | VAL24 | |
B | ASP49 | |
B | HIS112 | |
B | SER149 | |
B | GLN171 | |
B | TRP197 | |
B | LYS240 | |
B | ARG246 | |
A | VAL24 | |
A | ASP49 | |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | SITE: Lowers pKa of active site Tyr => ECO:0000250 |
Chain | Residue | Details |
A | LYS79 | |
B | LYS79 | |