4G35

Mcl-1 in complex with a biphenyl cross-linked Noxa peptide.

4G35 の概要

• エントリーDOI: 10.2210/pdb4g35/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000921
• 分子名称: Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Noxa BH3 peptide (cysteine-mediated cross-linked), 4,4'-bis(bromomethyl)biphenyl, ... (4 entities in total)
• 機能のキーワード: apoptosis, bh3 domain, bcl-2 family, apoptosis-inhibitor complex, apoptosis/inhibitor
• 由来する生物種: Mus musculus (mouse); 詳細
• 細胞内の位置: Membrane; Single-pass membrane protein (By similarity): P97287
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 21158.78

構造登録者

Drake, E.,Edwardraja, S.,Lin, Q.,Gulick, A.M. (登録日: 2012-07-13, 公開日: 2012-12-05, 最終更新日: 2013-06-26)

• 主引用文献: Muppidi, A.,Doi, K.,Edwardraja, S.,Drake, E.J.,Gulick, A.M.,Wang, H.G.,Lin, Q.; Rational design of proteolytically stable, cell-permeable peptide-based selective Mcl-1 inhibitors.; J.Am.Chem.Soc., 134:14734-14737, 2012; PubMed: 22920569; DOI: 10.1021/ja306864v

実験手法

X-RAY DIFFRACTION (2 Å)