4G2I

Structural basis for the accommodation of bis- and tris-aromatic derivatives in Vitamin D Nuclear Receptor

Summary for 4G2I

Entry DOI	10.2210/pdb4g2i/pdb
Related	1DB1
Descriptor	Vitamin D3 receptor, (3E,5E)-6-(3-{2-[3,4-bis(hydroxymethyl)phenyl]ethyl}phenyl)-1,1,1-trifluoro-2-(trifluoromethyl)octa-3,5-dien-2-ol (3 entities in total)
Functional Keywords	vdr, transcription regulation, nuclear receptor, alpha helical sandwich, ligand, dna, phosphorylation, nucleus, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P11473
Total number of polymer chains	1
Total formula weight	29880.33
Authors	Ciesielski, F.,Sato, Y.,Moras, D.,Rochel, N. (deposition date: 2012-07-12, release date: 2012-09-26, Last modification date: 2024-02-28)
Primary citation	Ciesielski, F.,Sato, Y.,Chebaro, Y.,Moras, D.,Dejaegere, A.,Rochel, N. Structural basis for the accommodation of bis- and tris-aromatic derivatives in vitamin d nuclear receptor. J.Med.Chem., 55:8440-8449, 2012 Cited by PubMed: 22957834 DOI: 10.1021/jm300858s PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation