4G2I

Structural basis for the accommodation of bis- and tris-aromatic derivatives in Vitamin D Nuclear Receptor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE 0VQ A 501

Chain	Residue
A	TYR143
A	TRP286
A	VAL300
A	HIS305
A	LEU309
A	LEU313
A	HIS397
A	TYR401
A	LEU404
A	LEU414
A	VAL418
A	TYR147
A	PHE422
A	LEU227
A	LEU233
A	VAL234
A	SER237
A	ARG274
A	SER275
A	SER278

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:10678179, ECO:0000269|PubMed:11344298, ECO:0007744|PDB:1DB1, ECO:0007744|PDB:1IE8

Chain	Residue	Details
A	TYR143
A	LEU325

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:10678179, ECO:0000269|PubMed:11344298, ECO:0007744|PDB:1DB1

Chain	Residue	Details
A	CYS288

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:10678179, ECO:0000269|PubMed:11344298, ECO:0007744|PDB:1IE8

Chain	Residue	Details
A	GLU329
A	GLN356

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site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:10678179, ECO:0000269|PubMed:11344298

Chain

Residue

Details

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