4FZ3

Crystal structure of SIRT3 in complex with acetyl p53 peptide coupled with 4-amino-7-methylcoumarin

Summary for 4FZ3

• Entry DOI: 10.2210/pdb4fz3/pdb
• Descriptor: NAD-dependent protein deacetylase sirtuin-3, mitochondrial, peptide from Cellular tumor antigen p53, ZINC ION, ... (4 entities in total)
• Functional Keywords: zinc-binding motif, rossmann fold, nad-dependent deacetylase, mitochondrial, hydrolase-hydrolase substrate complex, hydrolase/hydrolase substrate
• Biological source: Homo sapiens (human); More
• Cellular location: Mitochondrion matrix: Q9NTG7; Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• Total number of polymer chains: 2
• Total formula weight: 32258.50

Authors

Liu, D.,Wu, J.,Zhang, D.,Chen, K.,Jiang, H.,Liu, H. (deposition date: 2012-07-06, release date: 2013-03-20, Last modification date: 2023-12-06)

• Primary citation: Wu, J.,Zhang, D.,Chen, L.,Li, J.,Wang, J.,Ning, C.,Yu, N.,Zhao, F.,Chen, D.,Chen, X.,Chen, K.,Jiang, H.,Liu, H.,Liu, D.; Discovery and Mechanism Study of SIRT1 Activators that Promote the Deacetylation of Fluorophore-Labeled Substrate; J.Med.Chem., 56:761-780, 2013; PubMed: 23316803; DOI: 10.1021/jm301032j

Experimental method

X-RAY DIFFRACTION (2.1 Å)