4FI8
Kinetic Stabilization of transthyretin through covalent modification of K15 by 4-bromo-3-(5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)-benzenesulfonamide
Summary for 4FI8
Entry DOI | 10.2210/pdb4fi8/pdb |
Related | 3HJ0 4FI6 4FI7 |
Descriptor | Transthyretin, 4-bromo-3-[5-(3,5-dichloro-4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]benzenesulfonyl fluoride (3 entities in total) |
Functional Keywords | hormone, binding protein, covalent kinetic stabilizer, hormone-hormone inhibitor complex, hormone/hormone inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 28490.88 |
Authors | Connelly, S.,Grimster, N.,Wilson, I.A.,Kelly, J.W. (deposition date: 2012-06-08, release date: 2013-02-20, Last modification date: 2023-09-13) |
Primary citation | Grimster, N.P.,Connelly, S.,Baranczak, A.,Dong, J.,Krasnova, L.B.,Sharpless, K.B.,Powers, E.T.,Wilson, I.A.,Kelly, J.W. Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate. J.Am.Chem.Soc., 135:5656-5668, 2013 Cited by PubMed: 23350654DOI: 10.1021/ja311729d PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.22 Å) |
Structure validation
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