4FCO
Crystal structure of bace1 with its inhibitor
Summary for 4FCO
Entry DOI | 10.2210/pdb4fco/pdb |
Related | 4FGX |
Descriptor | Beta-secretase 1, SULFATE ION, N-[(2S,3R)-4-{[2-(1-benzylpiperidin-4-yl)ethyl]amino}-3-hydroxy-1-phenylbutan-2-yl]-5-[methyl(methylsulfonyl)amino]-N'-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide, ... (5 entities in total) |
Functional Keywords | hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 1 |
Total formula weight | 49371.19 |
Authors | |
Primary citation | Xu, Y.C.,Chen, W.Y.,Chen, T.T.,Li, L. Flexibility of the Flap in the Active Site of BACE1 as Revealed by Crystal Structures and MD simulations To be Published, 2012 |
Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
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