4FCB
Potent and Selective Phosphodiesterase 10A Inhibitors
Summary for 4FCB
Entry DOI | 10.2210/pdb4fcb/pdb |
Related | 4FCD |
Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | binding sites, cyclic amp, cyclic gmp, ligands, phosphodiesterase inhibitors, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q9Y233 |
Total number of polymer chains | 2 |
Total formula weight | 80185.26 |
Authors | Parris, K.D. (deposition date: 2012-05-24, release date: 2012-09-05, Last modification date: 2024-02-28) |
Primary citation | Malamas, M.S.,Stange, H.,Schindler, R.,Lankau, H.J.,Grunwald, C.,Langen, B.,Egerland, U.,Hage, T.,Ni, Y.,Erdei, J.,Fan, K.Y.,Parris, K.,Marquis, K.L.,Grauer, S.,Brennan, J.,Navarra, R.,Graf, R.,Harrison, B.L.,Robichaud, A.,Kronbach, T.,Pangalos, M.N.,Brandon, N.J.,Hoefgen, N. Novel triazines as potent and selective phosphodiesterase 10A inhibitors. Bioorg.Med.Chem.Lett., 22:5876-5884, 2012 Cited by PubMed: 22902656DOI: 10.1016/j.bmcl.2012.07.076 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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