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4FCB

Potent and Selective Phosphodiesterase 10A Inhibitors

Functional Information from GO Data
ChainGOidnamespacecontents
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0007165biological_processsignal transduction
A0008081molecular_functionphosphoric diester hydrolase activity
B0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
B0007165biological_processsignal transduction
B0008081molecular_functionphosphoric diester hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE ZN A 801
ChainResidue
AHIS519
AHIS553
AASP554
AASP664
AMG802
AHOH936
AHOH937

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG A 802
ChainResidue
AHOH907
AHOH917
AHOH937
AHOH938
AHOH940
AASP554
AZN801

site_idAC3
Number of Residues16
DetailsBINDING SITE FOR RESIDUE 0T7 A 803
ChainResidue
ATYR514
ALEU665
ASER667
AVAL668
ATYR683
APRO702
AMET703
AGLU711
AVAL712
AGLY715
AGLN716
APHE719
AHOH935
AHOH939
BLYS695
BLEU696

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE ZN B 801
ChainResidue
BHIS519
BHIS553
BASP554
BASP664
BMG802
BHOH901
BHOH918

site_idAC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG B 802
ChainResidue
BASP554
BZN801
BHOH901
BHOH918
BHOH919
BHOH922
BHOH924

site_idAC6
Number of Residues12
DetailsBINDING SITE FOR RESIDUE 0T7 B 803
ChainResidue
BTYR514
BLEU665
BVAL668
BILE682
BTYR683
BPHE686
BPRO702
BMET703
BGLU711
BGLY715
BGLN716
BPHE719

Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGfsNsY
ChainResidueDetails
AHIS553-TYR564

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:18477562, ECO:0007744|PDB:2ZMF
ChainResidueDetails
AASN562
ASER606
AGLN640
AMET659
BASN562
BSER606
BGLN640
BMET659

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PDB entries from 2024-07-10

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