4FBN

Insights into structural integration of the PLCgamma regulatory region and mechanism of autoinhibition and activation based on key roles of SH2 domains

4FBN の概要

• エントリーDOI: 10.2210/pdb4fbn/pdb
• 関連するPDBエントリー: 4EY0
• 分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (2 entities in total)
• 機能のキーワード: sh2 domain, plcgamma specific array, interaction domain, fibroblast growth factor receptor 1, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell projection, lamellipodium: P19174
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28578.17

構造登録者

Cole, A.R.,Mas-Droux, C.P.,Bunney, T.D.,Katan, M. (登録日: 2012-05-23, 公開日: 2012-10-31, 最終更新日: 2024-02-28)

• 主引用文献: Bunney, T.D.,Esposito, D.,Mas-Droux, C.,Lamber, E.,Baxendale, R.W.,Martins, M.,Cole, A.,Svergun, D.,Driscoll, P.C.,Katan, M.; Structural and Functional Integration of the PLCgamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation.; Structure, 20:2062-2075, 2012; PubMed: 23063561; DOI: 10.1016/j.str.2012.09.005

実験手法

X-RAY DIFFRACTION (2.4 Å)