4FAT

Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator

4FAT の概要

• エントリーDOI: 10.2210/pdb4fat/pdb
• 分子名称: Glutamate receptor 2, GLUTAMIC ACID, 2-({[4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, ... (7 entities in total)
• 機能のキーワード: transport protein, ion channel, chimera protein, membrane protein
• 由来する生物種: Rattus norvegicus (brown rat,rat,rats); 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P19491
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30390.70

構造登録者

Maclean, J.K.F.,Kazemier, B. (登録日: 2012-05-22, 公開日: 2012-07-11, 最終更新日: 2023-09-13)

• 主引用文献: Harms, J.E.,Benveniste, M.,Maclean, J.K.,Partin, K.M.,Jamieson, C.; Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy.; Neuropharmacology, 64:45-52, 2013; PubMed: 22735771; DOI: 10.1016/j.neuropharm.2012.06.008

実験手法

X-RAY DIFFRACTION (1.4 Å)