4F7S

Crystal structure of human CDK8/CYCC in the DMG-in conformation

Summary for 4F7S

• Entry DOI: 10.2210/pdb4f7s/pdb
• Related: 4G6L
• Descriptor: Cyclin-dependent kinase 8, Cyclin-C, N-(2-phenylethyl)quinazolin-4-amine, ... (6 entities in total)
• Functional Keywords: protein kinase complex, proteros, transferase-transcription-inhibitor complex, transferase/transcription/inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : P49336 P24863
• Total number of polymer chains: 2
• Total formula weight: 81803.15

Authors

Schneider, E.V.,Boettcher, J.,Huber, R.,Maskos, K. (deposition date: 2012-05-16, release date: 2013-05-01, Last modification date: 2023-09-13)

• Primary citation: Schneider, E.V.,Bottcher, J.,Huber, R.,Maskos, K.,Neumann, L.; Structure-kinetic relationship study of CDK8/CycC specific compounds.; Proc.Natl.Acad.Sci.USA, 110:8081-8086, 2013; PubMed: 23630251; DOI: 10.1073/pnas.1305378110

Experimental method

X-RAY DIFFRACTION (2.2 Å)