4F7S
Crystal structure of human CDK8/CYCC in the DMG-in conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Cyclin-dependent kinase 8 | polymer | 405 | 46990.8 | 1 | UniProt (P49336) Pfam (PF00069) In PDB | Homo sapiens (human) | Cell division protein kinase 8, Mediator complex subunit CDK8, Mediator of RNA polymerase II transcription subunit CDK8, Protein kinase K35 |
| 2 | B | Cyclin-C | polymer | 287 | 33710.1 | 1 | UniProt (P24863) Pfam (PF00134) Pfam (PF16899) In PDB | Homo sapiens (human) | SRB11 homolog, hSRB11 |
| 3 | A | N-(2-phenylethyl)quinazolin-4-amine | non-polymer | 249.3 | 1 | Chemie (0SW) | |||
| 4 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 13 | Chemie (EDO) | |||
| 5 | B | FORMIC ACID | non-polymer | 46.0 | 1 | Chemie (FMT) | |||
| 6 | water | water | 18.0 | 209 | Chemie (HOH) |
Sequence modifications
A: 1 - 403 (UniProt: P49336)
B: 1 - 283 (UniProt: P24863)
| PDB | External Database | Details |
|---|---|---|
| Asp -1 | - | expression tag |
| Lys 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Lys -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 80700.9 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 1102.2 | |
| All* | Total formula weight | 81803.1 |
