4F6Z

Mutagenesis of zinc ligand residue Cys221 reveals plasticity in the IMP-1 metallo-b-lactamase active site

Summary for 4F6Z

• Entry DOI: 10.2210/pdb4f6z/pdb
• Related: 4F6H
• Descriptor: Beta-lactamase, ZINC ION, CITRATE ANION, ... (4 entities in total)
• Functional Keywords: metallo-b-lactamase, b-lactamase, hydrolase
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 1
• Total formula weight: 26397.24

Authors

Horton, L.B.,Shanker, S.,Sankaran, B.,Mikulski, R.,Brown, N.G.,Phillips, K.,Lykissa, E.,Prasad, B.V.V.,Palzkill, T.G. (deposition date: 2012-05-15, release date: 2013-03-27, Last modification date: 2023-09-13)

• Primary citation: Horton, L.B.,Shanker, S.,Mikulski, R.,Brown, N.G.,Phillips, K.J.,Lykissa, E.,Venkataram Prasad, B.V.,Palzkill, T.; Mutagenesis of zinc ligand residue Cys221 reveals plasticity in the IMP-1 metallo-beta-lactamase active site; Antimicrob.Agents Chemother., 56:5667-5677, 2012; PubMed: 22908171; DOI: 10.1128/AAC.01276-12

Experimental method

X-RAY DIFFRACTION (2 Å)