4F5D

ERIS/STING in complex with ligand

4F5D の概要

• エントリーDOI: 10.2210/pdb4f5d/pdb
• 関連するPDBエントリー: 4F5E
• 分子名称: Transmembrane protein 173, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: receptor, immune system
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane ; Multi-pass membrane protein : Q86WV6
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 57985.77

構造登録者

Huang, Y.H.,Liu, X.Y.,Su, X.D. (登録日: 2012-05-13, 公開日: 2012-06-27, 最終更新日: 2024-03-20)

主引用文献

Huang, Y.H.,Liu, X.Y.,Du, X.X.,Jiang, Z.F.,Su, X.D.
The structural basis for the sensing and binding of cyclic di-GMP by STING
Nat.Struct.Mol.Biol., 19:728-730, 2012

PubMed Abstract: STING (stimulator of interferon genes) is an essential signaling adaptor that mediates cytokine production in response to microbial invasion by directly sensing bacterial secondary messengers such as the cyclic dinucleotide bis-(3'-5')-cyclic dimeric GMP (c-di-GMP). STING's structure and its binding mechanism to cyclic dinucleotides were unknown. We report here the crystal structures of the STING cytoplasmic domain and its complex with c-di-GMP, thus providing the structural basis for understanding STING function.

PubMed: 22728659
DOI: 10.1038/nsmb.2333

実験手法

X-RAY DIFFRACTION (3 Å)