4F23

Influenza A virus hemagglutinin H16 HA0 structure with an alpha-helix conformation in the cleavage site: a potential drug target

Summary for 4F23

• Entry DOI: 10.2210/pdb4f23/pdb
• Descriptor: Hemagglutinin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: hemagglutinin, sialic acid, glycolysation, membrane, viral protein
• Biological source: Influenza A virus
• Total number of polymer chains: 3
• Total formula weight: 175954.40

Authors

Lu, X.,Shi, Y.,Gao, F.,Xiao, H.,Qi, J.,Gao, G.F. (deposition date: 2012-05-07, release date: 2012-11-21, Last modification date: 2020-07-29)

• Primary citation: Lu, X.,Shi, Y.,Gao, F.,Xiao, H.,Wang, M.,Qi, J.,Gao, G.F.; Insights into Avian Influenza Virus Pathogenicity: the Hemagglutinin Precursor HA0 of Subtype H16 Has an Alpha-Helix Structure in Its Cleavage Site with Inefficient HA1/HA2 Cleavage.; J.Virol., 86:12861-12870, 2012; PubMed: 22993148; DOI: 10.1128/JVI.01606-12

Experimental method

X-RAY DIFFRACTION (1.7 Å)