4F1M
Crystal Structure of the G1179S Roco4 Kinase Domain bound to AppCp from D. discoideum.
Summary for 4F1M
Entry DOI | 10.2210/pdb4f1m/pdb |
Related | 4F0F 4F0G 4F1O 4F1T |
Descriptor | Serine/threonine-protein kinase roco4, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (5 entities in total) |
Functional Keywords | protein kinase, lrrk2, roco, kinase, atp-binding, nucleotide-binding, serine/threonine-protein kinase, transferase, signaling protein |
Biological source | Dictyostelium discoideum (Slime mold) |
Total number of polymer chains | 1 |
Total formula weight | 33385.32 |
Authors | Gilsbach, B.K.,Vetter, I.R.,Wittinghofer, A.,Kortholt, A. (deposition date: 2012-05-07, release date: 2012-06-27, Last modification date: 2023-09-13) |
Primary citation | Gilsbach, B.K.,Ho, F.Y.,Vetter, I.R.,van Haastert, P.J.,Wittinghofer, A.,Kortholt, A. Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations. Proc.Natl.Acad.Sci.USA, 109:10322-10327, 2012 Cited by PubMed: 22689969DOI: 10.1073/pnas.1203223109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.04 Å) |
Structure validation
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