4EZM

Crystal structure of the human IgE-Fc(epsilon)3-4 bound to its B cell receptor derCD23

4EZM の概要

• エントリーDOI: 10.2210/pdb4ezm/pdb
• 関連するPDBエントリー: 1FP5 1T8C 1T8D 2H2R 2H2T 2WQR 3H9Y 3H9Z 3HA0
• 分子名称: Ig epsilon chain C region, Low affinity immunoglobulin epsilon Fc receptor, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: immunoglobulin fold lectin, antibody receptor, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane; Single-pass type II membrane protein: P06734
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 252336.04

構造登録者

Dhaliwal, B.,Yuan, D.,Sutton, B.J. (登録日: 2012-05-03, 公開日: 2012-07-18, 最終更新日: 2024-10-16)

• 主引用文献: Dhaliwal, B.,Yuan, D.,Pang, M.O.,Henry, A.J.,Cain, K.,Oxbrow, A.,Fabiane, S.M.,Beavil, A.J.,McDonnell, J.M.,Gould, H.J.,Sutton, B.J.; Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor Fc{varepsilon}RI.; Proc.Natl.Acad.Sci.USA, 109:12686-12691, 2012; PubMed: 22802656; DOI: 10.1073/pnas.1207278109

実験手法

X-RAY DIFFRACTION (3.1 Å)