4EZ5
CDK6 (monomeric) in complex with inhibitor
Summary for 4EZ5
Entry DOI | 10.2210/pdb4ez5/pdb |
Related | 3NUP 3NUX |
Descriptor | Cyclin-dependent kinase 6, {5-[4-(dimethylamino)piperidin-1-yl]-1H-imidazo[4,5-b]pyridin-2-yl}[2-(isoquinolin-4-yl)pyridin-4-yl]methanone (2 entities in total) |
Functional Keywords | protein kinase, atp binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q00534 |
Total number of polymer chains | 1 |
Total formula weight | 35496.77 |
Authors | Chopra, R.,Xu, M. (deposition date: 2012-05-02, release date: 2013-02-06, Last modification date: 2023-09-13) |
Primary citation | Cho, Y.S.,Angove, H.,Brain, C.,Chen, C.H.,Cheng, H.,Cheng, R.,Chopra, R.,Chung, K.,Congreve, M.,Dagostin, C.,Davis, D.J.,Feltell, R.,Giraldes, J.,Hiscock, S.D.,Kim, S.,Kovats, S.,Lagu, B.,Lewry, K.,Loo, A.,Lu, Y.,Luzzio, M.,Maniara, W.,McMenamin, R.,Mortenson, P.N.,Benning, R.,O'Reilly, M.,Rees, D.C.,Shen, J.,Smith, T.,Wang, Y.,Williams, G.,Woolford, A.J.,Wrona, W.,Xu, M.,Yang, F.,Howard, S. Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors. ACS Med Chem Lett, 3:445-449, 2012 Cited by PubMed: 24900493DOI: 10.1021/ml200241a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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