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4EVY

Crystal structure of aminoglycoside antibiotic 6'-N-acetyltransferase AAC(6')-Ig from Acinetobacter haemolyticus in complex with tobramycin

Summary for 4EVY
Entry DOI10.2210/pdb4evy/pdb
DescriptorAminoglycoside N(6')-acetyltransferase type 1, TOBRAMYCIN, POTASSIUM ION, ... (5 entities in total)
Functional Keywordscenter for structural genomics of infectious diseases (csgid), niaid, national institute of allergy and infectious diseases, gnat superfamily, gcn5-related n-acetyltransferase superfamily, n-acetyltransferase fold, antibiotic resistance, acetyl coenzyme a, intracellular, transferase-antibiotic complex, transferase/antibiotic
Biological sourceAcinetobacter haemolyticus
Total number of polymer chains2
Total formula weight38918.17
Authors
Stogios, P.J.,Evdokimova, E.,Minasov, G.,Yim, V.,Courvalin, P.,Savchenko, A.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2012-04-26, release date: 2012-05-09, Last modification date: 2023-09-13)
Primary citationStogios, P.J.,Kuhn, M.L.,Evdokimova, E.,Law, M.,Courvalin, P.,Savchenko, A.
Structural and Biochemical Characterization of Acinetobacter spp. Aminoglycoside Acetyltransferases Highlights Functional and Evolutionary Variation among Antibiotic Resistance Enzymes.
ACS Infect Dis., 3:132-143, 2017
Cited by
PubMed: 27785912
DOI: 10.1021/acsinfecdis.6b00058
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.768 Å)
Structure validation

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