4EVY
Crystal structure of aminoglycoside antibiotic 6'-N-acetyltransferase AAC(6')-Ig from Acinetobacter haemolyticus in complex with tobramycin
Summary for 4EVY
Entry DOI | 10.2210/pdb4evy/pdb |
Descriptor | Aminoglycoside N(6')-acetyltransferase type 1, TOBRAMYCIN, POTASSIUM ION, ... (5 entities in total) |
Functional Keywords | center for structural genomics of infectious diseases (csgid), niaid, national institute of allergy and infectious diseases, gnat superfamily, gcn5-related n-acetyltransferase superfamily, n-acetyltransferase fold, antibiotic resistance, acetyl coenzyme a, intracellular, transferase-antibiotic complex, transferase/antibiotic |
Biological source | Acinetobacter haemolyticus |
Total number of polymer chains | 2 |
Total formula weight | 38918.17 |
Authors | Stogios, P.J.,Evdokimova, E.,Minasov, G.,Yim, V.,Courvalin, P.,Savchenko, A.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2012-04-26, release date: 2012-05-09, Last modification date: 2023-09-13) |
Primary citation | Stogios, P.J.,Kuhn, M.L.,Evdokimova, E.,Law, M.,Courvalin, P.,Savchenko, A. Structural and Biochemical Characterization of Acinetobacter spp. Aminoglycoside Acetyltransferases Highlights Functional and Evolutionary Variation among Antibiotic Resistance Enzymes. ACS Infect Dis., 3:132-143, 2017 Cited by PubMed: 27785912DOI: 10.1021/acsinfecdis.6b00058 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.768 Å) |
Structure validation
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