4EU2

Crystal structure of 20s proteasome with novel inhibitor K-7174

Summary for 4EU2

• Entry DOI: 10.2210/pdb4eu2/pdb
• Descriptor: Proteasome component C7-alpha, Proteasome component PUP3, Proteasome component C11, ... (16 entities in total)
• Functional Keywords: proteasome inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Saccharomyces cerevisiae (Baker's yeast); More
• Cellular location: Cytoplasm: P21243 P25451 P22141 P30656 P23724 P30657 P23639 P23638 P40303 P32379 P40302 P21242 P38624 P25043
• Total number of polymer chains: 28
• Total formula weight: 707188.29

Authors

Kikuchi, J.,Shibayama, N.,Yamada, S.,Wada, T.,Nobuyoshi, M.,Izumi, T.,Akutsu, M.,Kano, Y.,Ohki, M.,Sugiyama, K.,Park, S.-Y.,Furukawa, Y. (deposition date: 2012-04-25, release date: 2013-05-01, Last modification date: 2024-03-20)

• Primary citation: Kikuchi, J.,Shibayama, N.,Yamada, S.,Wada, T.,Nobuyoshi, M.,Izumi, T.,Akutsu, M.,Kano, Y.,Sugiyama, K.,Ohki, M.,Park, S.Y.,Furukawa, Y.; Homopiperazine derivatives as a novel class of proteasome inhibitors with a unique mode of proteasome binding.; Plos One, 8:e60649-e60649, 2013; PubMed: 23593271; DOI: 10.1371/journal.pone.0060649

Experimental method

X-RAY DIFFRACTION (2.509 Å)