4ELM

Crystal structure of the mouse CD1d-lysosulfatide-Hy19.3 TCR complex

4ELM の概要

• エントリーDOI: 10.2210/pdb4elm/pdb
• 関連するPDBエントリー: 4ELK
• 分子名称: Antigen-presenting glycoprotein CD1d1, Beta-2 microglobulin, Hy19.3 TCR alpha chain (mouse variable domain, human constant domain), ... (9 entities in total)
• 機能のキーワード: antigen presentation, glycolipid, nkt cells, immune system
• 由来する生物種: Mus musculus (mouse); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 194630.49

構造登録者

Girardi, E.,Maricic, I.,Wang, J.,Mac, T.T.,Iyer, P.,Kumar, V.,Zajonc, D.M. (登録日: 2012-04-11, 公開日: 2012-07-25, 最終更新日: 2024-11-06)

主引用文献

Girardi, E.,Maricic, I.,Wang, J.,Mac, T.T.,Iyer, P.,Kumar, V.,Zajonc, D.M.
Type II natural killer T cells use features of both innate-like and conventional T cells to recognize sulfatide self antigens.
Nat.Immunol., 13:851-856, 2012

PubMed Abstract: Glycolipids presented by the major histocompatibility complex (MHC) class I homolog CD1d are recognized by natural killer T cells (NKT cells) characterized by either a semi-invariant T cell antigen receptor (TCR) repertoire (type I NKT cells or iNKT cells) or a relatively variable TCR repertoire (type II NKT cells). Here we describe the structure of a type II NKT cell TCR in complex with CD1d-lysosulfatide. Both TCR α-chains and TCR β-chains made contact with the CD1d molecule with a diagonal footprint, typical of MHC-TCR interactions, whereas the antigen was recognized exclusively with a single TCR chain, similar to the iNKT cell TCR. Type II NKT cell TCRs, therefore, recognize CD1d-sulfatide complexes by a distinct recognition mechanism characterized by the TCR-binding features of both iNKT cells and conventional peptide-reactive T cells.

PubMed: 22820602
DOI: 10.1038/ni.2371

実験手法

X-RAY DIFFRACTION (3.48 Å)