4EJG
Human Cytochrome P450 2A13 in complex with Nicotine
Summary for 4EJG
Entry DOI | 10.2210/pdb4ejg/pdb |
Related | 2P85 3T3S 4EJH 4EJI 4EJJ |
Descriptor | Cytochrome P450 2A13, PROTOPORPHYRIN IX CONTAINING FE, (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, ... (5 entities in total) |
Functional Keywords | cyp2a13, cytochrome p450 2a13, heme protein, p450 2a13, monooxygenase, drug metabolism, xenobiotic metabolism, endoplasmic reticulum, membrane, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein: Q16696 |
Total number of polymer chains | 8 |
Total formula weight | 444110.98 |
Authors | DeVore, N.M.,Scott, E.E. (deposition date: 2012-04-06, release date: 2012-06-06, Last modification date: 2023-09-13) |
Primary citation | DeVore, N.M.,Scott, E.E. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone binding and access channel in human cytochrome P450 2A6 and 2A13 enzymes. J.Biol.Chem., 287:26576-26585, 2012 Cited by PubMed: 22700965DOI: 10.1074/jbc.M112.372813 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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