4EFK
Pantothenate synthetase in complex with N,N-DIMETHYLTHIOPHENE-3-SULFONAMIDE
Summary for 4EFK
Entry DOI | 10.2210/pdb4efk/pdb |
Related | 3IME 4DDH 4DDK 4DDM 4DE5 4EF6 |
Descriptor | Pantothenate synthetase, N,N-dimethylthiophene-3-sulfonamide, GLYCEROL, ... (7 entities in total) |
Functional Keywords | alpha beta/3-layer sandwich/rossmann fold, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Mycobacterium tuberculosis |
Cellular location | Cytoplasm (Potential): P0A5R0 |
Total number of polymer chains | 2 |
Total formula weight | 64337.92 |
Authors | Ciulli, A.,Silvestre, H.L.,Blundell, T.L.,Abell, C. (deposition date: 2012-03-29, release date: 2013-03-13, Last modification date: 2024-02-28) |
Primary citation | Silvestre, H.L.,Blundell, T.L.,Abell, C.,Ciulli, A. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery. Proc.Natl.Acad.Sci.USA, 110:12984-12989, 2013 Cited by PubMed: 23872845DOI: 10.1073/pnas.1304045110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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