4ECE

Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with guanine

4ECE の概要

• エントリーDOI: 10.2210/pdb4ece/pdb
• 関連するPDBエントリー: 4EAR 4EB8
• 分子名称: Purine nucleoside phosphorylase, GUANINE (3 entities in total)
• 機能のキーワード: transferase, pnp, guanine, purine nucleoside phosphorylase, nucleoside binding, purine base binding, purine-nucleoside phosphorylase activity, drug binding, transferring glycosyl groups, phosphate ion binding, intracellular, cytosol
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytoskeleton (By similarity): P00491
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 217669.53

構造登録者

Haapalainen, A.M.,Ho, M.C.,Suarez, J.J.,Almo, S.C.,Schramm, V.L. (登録日: 2012-03-26, 公開日: 2013-02-06, 最終更新日: 2024-02-28)

• 主引用文献: Suarez, J.,Haapalainen, A.M.,Cahill, S.M.,Ho, M.C.,Yan, F.,Almo, S.C.,Schramm, V.L.; Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography.; Chem.Biol., 20:212-222, 2013; PubMed: 23438750; DOI: 10.1016/j.chembiol.2013.01.009

実験手法

X-RAY DIFFRACTION (2.6 Å)