4EBW
Structure of Focal Adhesion Kinase catalytic domain in complex with novel allosteric inhibitor
Summary for 4EBW
Entry DOI | 10.2210/pdb4ebw/pdb |
Related | 4EBV |
Descriptor | Focal adhesion kinase 1, 1-ethyl-8-(4-ethylphenyl)-5-methyl-1,5-dihydropyrazolo[4,3-c][2,1]benzothiazine 4,4-dioxide (3 entities in total) |
Functional Keywords | kinase domain, allosteric inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell junction, focal adhesion: Q05397 |
Total number of polymer chains | 1 |
Total formula weight | 35461.78 |
Authors | Iwatani, M.,Iwata, H.,Okabe, A.,Skene, R.J.,Tomita, N.,Hayashi, Y.,Aramaki, Y.,Hosfield, D.J.,Hori, A.,Baba, A.,Miki, H. (deposition date: 2012-03-25, release date: 2012-07-25, Last modification date: 2013-03-27) |
Primary citation | Iwatani, M.,Iwata, H.,Okabe, A.,Skene, R.J.,Tomita, N.,Hayashi, Y.,Aramaki, Y.,Hosfield, D.J.,Hori, A.,Baba, A.,Miki, H. Discovery and characterization of novel allosteric FAK inhibitors. Eur.J.Med.Chem., 61:49-60, 2013 Cited by PubMed: 22819505DOI: 10.1016/j.ejmech.2012.06.035 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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