4EBW
Structure of Focal Adhesion Kinase catalytic domain in complex with novel allosteric inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Focal adhesion kinase 1 | polymer | 304 | 35094.3 | 1 | UniProt (Q05397) Pfam (PF07714) In PDB | Homo sapiens (human) | FADK 1, Focal adhesion kinase-related nonkinase, FRNK, Protein phosphatase 1 regulatory subunit 71, PPP1R71, Protein-tyrosine kinase 2, p125FAK, pp125FAK |
2 | A | 1-ethyl-8-(4-ethylphenyl)-5-methyl-1,5-dihydropyrazolo[4,3-c][2,1]benzothiazine 4,4-dioxide | non-polymer | 367.5 | 1 | Chemie (0PF) | |||
3 | water | water | 18.0 | 48 | Chemie (HOH) |
Sequence modifications
A: 411 - 686 (UniProt: Q05397)
PDB | External Database | Details |
---|---|---|
Met 383 | - | INITIATING METHIONINE |
Ser 384 | - | EXPRESSION TAG |
Tyr 385 | - | EXPRESSION TAG |
Tyr 386 | - | EXPRESSION TAG |
His 387 | - | EXPRESSION TAG |
His 388 | - | EXPRESSION TAG |
His 389 | - | EXPRESSION TAG |
His 390 | - | EXPRESSION TAG |
His 391 | - | EXPRESSION TAG |
His 392 | - | EXPRESSION TAG |
Asp 393 | - | EXPRESSION TAG |
Tyr 394 | - | EXPRESSION TAG |
Asp 395 | - | EXPRESSION TAG |
Ile 396 | - | EXPRESSION TAG |
Pro 397 | - | EXPRESSION TAG |
Thr 398 | - | EXPRESSION TAG |
Thr 399 | - | EXPRESSION TAG |
Glu 400 | - | EXPRESSION TAG |
Asn 401 | - | EXPRESSION TAG |
Leu 402 | - | EXPRESSION TAG |
Tyr 403 | - | EXPRESSION TAG |
Phe 404 | - | EXPRESSION TAG |
Gln 405 | - | EXPRESSION TAG |
Gly 406 | - | EXPRESSION TAG |
Ala 407 | - | EXPRESSION TAG |
Met 408 | - | EXPRESSION TAG |
Gly 409 | - | EXPRESSION TAG |
Ser 410 | - | EXPRESSION TAG |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 35094.3 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 367.5 | |
All* | Total formula weight | 35461.8 |