4EAW

HCV NS5B in complex with IDX375

Summary for 4EAW

• Entry DOI: 10.2210/pdb4eaw/pdb
• Descriptor: RNA-directed RNA polymerase, N-{(1S)-3-[(5S)-5-tert-butyl-1-(3,3-dimethylbutyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-1-ethoxy-1-oxido-1,4-dihydro-2,4,1-benzodiazaphosphinin-7-yl}methanesulfonamide, SULFATE ION, ... (6 entities in total)
• Functional Keywords: transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Hepatitis C virus subtype 1b (HCV)
• Cellular location: Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : O92972
• Total number of polymer chains: 2
• Total formula weight: 127449.66

Authors

Dousson, C.B.,Paparin, J.-L.,Surleraux, D.,Augustin, M.,Blaesse, M.,Hoeppner, S.,Krapp, S.,Wenzkowski, C. (deposition date: 2012-03-22, release date: 2013-03-27, Last modification date: 2024-02-28)

• Primary citation: Dousson, C.B.,Paparin, J.-L.,Surleraux, D.,Augustin, M.,Blaesse, M.,Hoeppner, S.,Krapp, S.,Wenzkowski, C.; HCV NS5B in complex with IDX375; To be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)