4EAW
HCV NS5B in complex with IDX375
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | RNA-directed RNA polymerase | polymer | 562 | 62578.7 | 2 | UniProt (O92972) Pfam (PF00998) | Hepatitis C virus subtype 1b (HCV) | NS5B, p68 |
| 2 | C, N (A, B) | N-{(1S)-3-[(5S)-5-tert-butyl-1-(3,3-dimethylbutyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-1-ethoxy-1-oxido-1,4-dihydro-2,4,1-benzodiazaphosphinin-7-yl}methanesulfonamide | non-polymer | 540.6 | 2 | Chemie (0NQ) | |||
| 3 | D, E, F, G, H... (A, B) | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
| 4 | J, K, Q (A, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 3 | Chemie (PEG) | |||
| 5 | L, M (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 6 | R, S (A, B) | water | water | 18.0 | 730 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 562 (UniProt: O92972)
| PDB | External Database | Details |
|---|---|---|
| Tyr 316 | Asn 2735 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 125157.4 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 2292.2 | |
| All* | Total formula weight | 127449.7 |
