4EA3
Structure of the N/OFQ Opioid Receptor in Complex with a Peptide Mimetic
Summary for 4EA3
Entry DOI | 10.2210/pdb4ea3/pdb |
Descriptor | Fusion protein of Nociceptin receptor and cytochrome b562, 1-benzyl-N-[3-(1'H,3H-spiro[2-benzofuran-1,4'-piperidin]-1'-yl)propyl]-D-prolinamide, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (6 entities in total) |
Functional Keywords | psi-biology gpcr network, structural genomics, gpcr membrane protein 7tm nop orl1 cytochrome b562, receptor, nociceptin orphanin fq compound 24 opioid, fusion, membrane transmembrane, signaling protein |
Biological source | Escherichia coli More |
Cellular location | Cell membrane; Multi-pass membrane protein: P41146 |
Total number of polymer chains | 2 |
Total formula weight | 98018.35 |
Authors | Thompson, A.A.,Liu, W.,Chun, E.,Katritch, V.,Wu, H.,Vardy, E.,Huang, X.P.,Trapella, C.,Guerrini, R.,Calo, G.,Roth, B.L.,Cherezov, V.,Stevens, R.C.,GPCR Network (GPCR) (deposition date: 2012-03-22, release date: 2012-04-25, Last modification date: 2023-09-13) |
Primary citation | Thompson, A.A.,Liu, W.,Chun, E.,Katritch, V.,Wu, H.,Vardy, E.,Huang, X.P.,Trapella, C.,Guerrini, R.,Calo, G.,Roth, B.L.,Cherezov, V.,Stevens, R.C. Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic. Nature, 485:395-399, 2012 Cited by PubMed: 22596163DOI: 10.1038/nature11085 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.013 Å) |
Structure validation
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