4E9C

The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with LDPPLHSpTA phosphopeptide

4E9C の概要

• エントリーDOI: 10.2210/pdb4e9c/pdb
• 関連するPDBエントリー: 4E67 4E9D
• 関連するBIRD辞書のPRD_ID: PRD_000809
• 分子名称: Serine/threonine-protein kinase PLK1, LDPPLHSpTA phosphopeptide, 2-(2-METHOXYETHOXY)ETHANOL, ... (5 entities in total)
• 機能のキーワード: serine/threonine kinase, transferase, phosphoprotein binding domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28142.99

構造登録者

Sledz, P.,Hyvonen, M.,Lang, S.,Stubbs, C.J.,Abell, C. (登録日: 2012-03-21, 公開日: 2012-10-10, 最終更新日: 2024-11-06)

主引用文献

Sledz, P.,Lang, S.,Stubbs, C.J.,Abell, C.
High-throughput interrogation of ligand binding mode using a fluorescence-based assay.
Angew. Chem. Int. Ed. Engl., 51:7680-7683, 2012

PubMed Abstract: Probing the pocket: A high-throughput fluorescence-based thermal shift (FTS) assay utilized different forms of a protein (in gray) to establish the binding mode of a ligand (see picture). The assay serves in the rapid evaluation of structure-activity binding-mode relationships for a series of ligands of Plk1, an important target of anticancer therapy.

PubMed: 22730171
DOI: 10.1002/anie.201202660

実験手法

X-RAY DIFFRACTION (1.7 Å)