4E90
Human phosphodiesterase 9 in complex with inhibitors
Summary for 4E90
Entry DOI | 10.2210/pdb4e90/pdb |
Related | 3JSW |
Descriptor | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Isoform PDE9A1: Cell projection, ruffle membrane. Isoform PDE9A2: Cell projection, ruffle membrane. Isoform PDE9A3: Cytoplasm. Isoform PDE9A17: Cytoplasm: O76083 |
Total number of polymer chains | 2 |
Total formula weight | 78696.20 |
Authors | |
Primary citation | Claffey, M.M.,Helal, C.J.,Verhoest, P.R.,Kang, Z.,Fors, K.S.,Jung, S.,Zhong, J.,Bundesmann, M.W.,Hou, X.,Lui, S.,Kleiman, R.J.,Vanase-Frawley, M.,Schmidt, A.W.,Menniti, F.,Schmidt, C.J.,Hoffman, W.E.,Hajos, M.,McDowell, L.,O'Connor, R.E.,Macdougall-Murphy, M.,Fonseca, K.R.,Becker, S.L.,Nelson, F.R.,Liras, S. Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors. J.Med.Chem., 55:9055-9068, 2012 Cited by PubMed: 23025719DOI: 10.1021/jm3009635 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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