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4E90

Human phosphodiesterase 9 in complex with inhibitors

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9Apolymer32938862.92UniProt (O76083)
Pfam (PF00233)
In PDB
Homo sapiens (human)
2A, BZINC IONnon-polymer65.42Chemie (ZN)
3A, BMAGNESIUM IONnon-polymer24.32Chemie (MG)
4A, B6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-onenon-polymer395.52Chemie (7RG)
5waterwater18.0313Chemie (HOH)
Sequence modifications
A, B: 182 - 506 (UniProt: O76083)
PDBExternal DatabaseDetails
Gly 178-expression tag
Ser 179-expression tag
His 180-expression tag
Met 181-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight77725.9
Non-Polymers*Number of molecules6
Total formula weight970.3
All*Total formula weight78696.2
*Water molecules are not included.

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PDB entries from 2024-09-04

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