4E4Q
Crystal structure of PPARgamma with the ligand FS214
Summary for 4E4Q
Entry DOI | 10.2210/pdb4e4q/pdb |
Related | 3B3K 3K8S 4E4K |
Descriptor | Peroxisome proliferator-activated receptor gamma, (2R)-3-phenyl-2-{[2'-(propan-2-yl)biphenyl-4-yl]oxy}propanoic acid (3 entities in total) |
Functional Keywords | bundle of alpha-helices and a small four-stranded beta-sheet, transcription factor, transcription |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P37231 |
Total number of polymer chains | 2 |
Total formula weight | 65748.09 |
Authors | Pochetti, G.,Montanari, R.,Loiodice, F.,Fracchiolla, G.,Laghezza, A.,Carbonara, G.,Piemontese, L.,Lavecchia, A.,Novellino, E. (deposition date: 2012-03-13, release date: 2013-01-23, Last modification date: 2024-02-28) |
Primary citation | Laghezza, A.,Pochetti, G.,Lavecchia, A.,Fracchiolla, G.,Faliti, S.,Piemontese, L.,Di Giovanni, C.,Iacobazzi, V.,Infantino, V.,Montanari, R.,Capelli, D.,Tortorella, P.,Loiodice, F. New 2-(Aryloxy)-3-phenylpropanoic Acids as Peroxisome Proliferator-Activated Receptor alpha/gamma Dual Agonists Able To Upregulate Mitochondrial Carnitine Shuttle System Gene Expression. J.Med.Chem., 56:60-72, 2013 Cited by PubMed: 23171045DOI: 10.1021/jm301018z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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