4E36

Crystal structure of the human Endoplasmic Reticulum Aminopeptidase 2 variant N392K

4E36 の概要

• エントリーDOI: 10.2210/pdb4e36/pdb
• 関連するPDBエントリー: 3SE6
• 分子名称: Endoplasmic reticulum aminopeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: thermolysin-like catalytic domain, hydrolase, aminopeptidase, zinc binding, glycosylation, endoplasmic reticulum
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 226783.30

構造登録者

Birtley, J.R.,Saridakis, E.,Pegias, P.,Stratikos, E.,Mavridis, I.M. (登録日: 2012-03-09, 公開日: 2012-08-29, 最終更新日: 2023-09-13)

• 主引用文献: Evnouchidou, I.,Birtley, J.,Seregin, S.,Papakyriakou, A.,Zervoudi, E.,Samiotaki, M.,Panayotou, G.,Giastas, P.,Petrakis, O.,Georgiadis, D.,Amalfitano, A.,Saridakis, E.,Mavridis, I.M.,Stratikos, E.; A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing.; J.Immunol., 189:2383-2392, 2012; PubMed: 22837489; DOI: 10.4049/jimmunol.1200918

実験手法

X-RAY DIFFRACTION (3.22 Å)