4E36

Crystal structure of the human Endoplasmic Reticulum Aminopeptidase 2 variant N392K

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Endoplasmic reticulum aminopeptidase 2	polymer	967	111530.5	2	UniProt (Q6P179) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838)	Homo sapiens (human)	Leukocyte-derived arginine aminopeptidase, L-RAP
2	C, D, F (C, D, F)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	3	In PDB GlyTouCan (G42666HT)
3	E (E)	alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81874LD)
4	G, M (A, B)	LYSINE	non-polymer		147.2	2	Chemie (LYS)
5	H, I, J, O (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
6	K, P (A, B)	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	2	Chemie (MES)
7	L, N (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
8	Q, R (A, B)	water	water		18.0	106	Chemie (HOH)

Sequence modifications

A, B: 1 - 960 (UniProt: Q6P179)

PDB	External Database	Details
Val 2	Phe 2	SEE REMARK 999
Arg 961	-	expression tag
His 962	-	expression tag
His 963	-	expression tag
His 964	-	expression tag
His 965	-	expression tag
His 966	-	expression tag
His 967	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	223060.9
Branched	Number of molecules	4
	Total formula weight	2021.9
Non-Polymers*	Number of molecules	10
	Total formula weight	1700.5
All*	Total formula weight	226783.3

*Water molecules are not included.