4DY7

Crystal structures of protease nexin-1 in complex with S195A thrombin

4DY7 の概要

• エントリーDOI: 10.2210/pdb4dy7/pdb
• 分子名称: Thrombin light chain, Thrombin heavy chain, Glia-derived nexin, ... (7 entities in total)
• 機能のキーワード: serpin, protease, heparin, cell surface, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734 P07093
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 154922.04

構造登録者

Huntington, J.A.,Li, W. (登録日: 2012-02-28, 公開日: 2012-08-15)

• 主引用文献: Li, W.,Huntington, J.A.; Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.; Blood, 120:459-467, 2012; PubMed: 22618708; DOI: 10.1182/blood-2012-03-415869

実験手法

X-RAY DIFFRACTION (2.8 Å)