4DQM
Revealing a marine natural product as a novel agonist for retinoic acid receptors with a unique binding mode and antitumor activity
Summary for 4DQM
Entry DOI | 10.2210/pdb4dqm/pdb |
Descriptor | Retinoic acid receptor alpha, Nuclear receptor coactivator 1, (5S)-4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohex-1-en-1-yl)deca-3,7-dien-1-yl]-5-hydroxyfuran-2(5H)-one, ... (4 entities in total) |
Functional Keywords | nuclear receptor transcription factor, ligand binding domain, transcription regulation, nucleus, transcription-transferase complex, transcription/transferase |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P10276 Q15788 |
Total number of polymer chains | 4 |
Total formula weight | 56091.71 |
Authors | |
Primary citation | Wang, S.,Wang, Z.,Lin, S.,Zheng, W.,Wang, R.,Jin, S.,Chen, J.,Jin, L.,Li, Y. Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells. Biochem.J., 446:79-87, 2012 Cited by PubMed: 22642567DOI: 10.1042/BJ20120726 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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