4DQM

Revealing a marine natural product as a novel agonist for retinoic acid receptors with a unique binding mode and antitumor activity

4DQM の概要

• エントリーDOI: 10.2210/pdb4dqm/pdb
• 分子名称: Retinoic acid receptor alpha, Nuclear receptor coactivator 1, (5S)-4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohex-1-en-1-yl)deca-3,7-dien-1-yl]-5-hydroxyfuran-2(5H)-one, ... (4 entities in total)
• 機能のキーワード: nuclear receptor transcription factor, ligand binding domain, transcription regulation, nucleus, transcription-transferase complex, transcription/transferase
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: P10276 Q15788
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 56091.71

構造登録者

Wang, S.,Wang, Z.,Lin, S.,Zheng, W.,Wang, R.,Jin, S.,Chen, J.,Jin, L.,Li, Y. (登録日: 2012-02-16, 公開日: 2012-10-03, 最終更新日: 2017-11-15)

• 主引用文献: Wang, S.,Wang, Z.,Lin, S.,Zheng, W.,Wang, R.,Jin, S.,Chen, J.,Jin, L.,Li, Y.; Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells.; Biochem.J., 446:79-87, 2012; PubMed: 22642567; DOI: 10.1042/BJ20120726

実験手法

X-RAY DIFFRACTION (2.75 Å)