4DQG

Crystal Structure of apo(G16C/L38C) HIV-1 Protease

Summary for 4DQG

Entry DOI	10.2210/pdb4dqg/pdb
Related	4DQB 4DQC 4DQE 4DQF 4DQH
Descriptor	Aspartyl protease, N-HYDROXYGUANIDINE, GLYCEROL, ... (7 entities in total)
Functional Keywords	hiv-1 protease, drug resistance, drug design, protease inhibitors, aids, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1 (HIV-1)
Total number of polymer chains	2
Total formula weight	22144.92
Authors	Schiffer, C.A.,Mittal, S. (deposition date: 2012-02-15, release date: 2012-03-07, Last modification date: 2017-11-15)
Primary citation	Mittal, S.,Cai, Y.,Nalam, M.N.,Bolon, D.N.,Schiffer, C.A. Hydrophobic core flexibility modulates enzyme activity in HIV-1 protease. J.Am.Chem.Soc., 134:4163-4168, 2012 Cited by PubMed: 22295904 DOI: 10.1021/ja2095766 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.79 Å)

Structure validation