4DKL

Crystal structure of the mu-opioid receptor bound to a morphinan antagonist

4DKL の概要

• エントリーDOI: 10.2210/pdb4dkl/pdb
• 分子名称: Mu-type opioid receptor, lysozyme chimera, methyl 4-{[(5beta,6alpha)-17-(cyclopropylmethyl)-3,14-dihydroxy-4,5-epoxymorphinan-6-yl]amino}-4-oxobutanoate, SULFATE ION, ... (8 entities in total)
• 機能のキーワード: g-protein coupled receptor, 7 transmembrane receptor, signaling protein-antagonist complex, signaling protein/antagonist
• 由来する生物種: Mus musculus (mouse, bacteriophage T4); 詳細
• 細胞内の位置: Cell membrane ; Multi- pass membrane protein : P42866
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 55761.67

構造登録者

Manglik, A.,Kruse, A.C.,Kobilka, T.S.,Thian, F.S.,Mathiesen, J.M.,Sunahara, R.K.,Pardo, L.,Weis, W.I.,Kobilka, B.K.,Granier, S. (登録日: 2012-02-03, 公開日: 2012-03-21, 最終更新日: 2023-09-13)

• 主引用文献: Manglik, A.,Kruse, A.C.,Kobilka, T.S.,Thian, F.S.,Mathiesen, J.M.,Sunahara, R.K.,Pardo, L.,Weis, W.I.,Kobilka, B.K.,Granier, S.; Crystal structure of the {mu}-opioid receptor bound to a morphinan antagonist.; Nature, 485:321-326, 2012; PubMed: 22437502; DOI: 10.1038/nature10954

実験手法

X-RAY DIFFRACTION (2.8 Å)