4DIH

X-ray structure of the complex between human alpha thrombin and thrombin binding aptamer in the presence of sodium ions

4DIH の概要

• エントリーDOI: 10.2210/pdb4dih/pdb
• 関連するPDBエントリー: 4DII
• 関連するBIRD辞書のPRD_ID: PRD_000020
• 分子名称: Prothrombin, Thrombin binding aptamer, ZINC ION, ... (9 entities in total)
• 機能のキーワード: protein-dna complex, serine protease, blood coagulation, aptamer, hydrolase-hydrolase inhibitor-dna complex, serine protease fold, dna aptamer, blood, g-quadruplex, hydrolase/hydrolase inhibitor/dna
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 39608.11

構造登録者

Russo Krauss, I.,Merlino, A.,Mazzarella, L.,Sica, F. (登録日: 2012-01-31, 公開日: 2012-07-18, 最終更新日: 2023-09-13)

• 主引用文献: Russo Krauss, I.,Merlino, A.,Randazzo, A.,Novellino, E.,Mazzarella, L.,Sica, F.; High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity.; Nucleic Acids Res., 40:8119-8128, 2012; PubMed: 22669903; DOI: 10.1093/nar/gks512

実験手法

X-RAY DIFFRACTION (1.8 Å)