4DHY

Crystal structure of human glucokinase in complex with glucose and activator

Summary for 4DHY

• Entry DOI: 10.2210/pdb4dhy/pdb
• Related: 3S41 3VE6 3VEV 3VF6 4DCH
• Descriptor: Glucokinase, alpha-D-glucopyranose, N,N-dimethyl-5-({2-methyl-6-[(5-methylpyrazin-2-yl)carbamoyl]-1-benzofuran-4-yl}oxy)pyrimidine-2-carboxamide, ... (5 entities in total)
• Functional Keywords: diabetes mellitus, disease mutation, glycolysis, transferase, transferase-transferase activator complex, transferase/transferase activator
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 53574.71

Authors

Liu, S. (deposition date: 2012-01-30, release date: 2012-02-08, Last modification date: 2023-09-13)

• Primary citation: Liu, S.,Ammirati, M.J.,Song, X.,Knafels, J.D.,Zhang, J.,Greasley, S.E.,Pfefferkorn, J.A.,Qiu, X.; Insights into Mechanism of Glucokinase Activation: OBSERVATION OF MULTIPLE DISTINCT PROTEIN CONFORMATIONS.; J.Biol.Chem., 287:13598-13610, 2012; PubMed: 22298776; DOI: 10.1074/jbc.M111.274126

Experimental method

X-RAY DIFFRACTION (2.38 Å)