4DFU

Inhibition of an antibiotic resistance enzyme: crystal structure of aminoglycoside phosphotransferase APH(2")-ID/APH(2")-IVA in complex with kanamycin inhibited with quercetin

Replaces:  3VCQReplaces:  3R82

Summary for 4DFU

• Entry DOI: 10.2210/pdb4dfu/pdb
• Related: 4DBX 4DE4 4DFB
• Descriptor: APH(2")-Id, KANAMYCIN A, 3,5,7,3',4'-PENTAHYDROXYFLAVONE, ... (5 entities in total)
• Functional Keywords: structural genomics, center for structural genomics of infectious diseases, csgid, eukaryotic protein kinase-like fold, transferase-antibiotic-inhibitor complex, aminoglycoside phosphotransferase, kinase, transferase, aminoglycosides, kanamycin, flavanoids, quercetin, intracellular, antibotic, transferase-antibotic-inhibitor complex, transferase/antibotic/inhibitor
• Biological source: Enterococcus casseliflavus
• Total number of polymer chains: 2
• Total formula weight: 78504.69

Authors

Stogios, P.J.,Minasov, G.,Dong, A.,Evdokimova, E.,Egorova, E.,Di Leo, R.,Li, H.,Shakya, T.,Wright, G.D.,Savchenko, A.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2012-01-24, release date: 2012-02-08, Last modification date: 2024-03-13)

• Primary citation: Shakya, T.,Stogios, P.J.,Waglechner, N.,Evdokimova, E.,Ejim, L.,Blanchard, J.E.,McArthur, A.G.,Savchenko, A.,Wright, G.D.; A small molecule discrimination map of the antibiotic resistance kinome.; Chem.Biol., 18:1591-1601, 2011; PubMed: 22195561; DOI: 10.1016/j.chembiol.2011.10.018

Experimental method

X-RAY DIFFRACTION (1.98 Å)