4DEP

Structure of the IL-1b signaling complex

4DEP の概要

• エントリーDOI: 10.2210/pdb4dep/pdb
• 分子名称: Interleukin-1 beta, Interleukin-1 receptor type 1, Interleukin-1 receptor accessory protein, ... (5 entities in total)
• 機能のキーワード: b-trefoil, immunoglobulin, immune system, extracellular
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 192862.82

構造登録者

Thomas, C.,Garcia, K.C. (登録日: 2012-01-21, 公開日: 2012-03-21, 最終更新日: 2024-10-30)

主引用文献

Thomas, C.,Bazan, J.F.,Garcia, K.C.
Structure of the activating IL-1 receptor signaling complex.
Nat.Struct.Mol.Biol., 19:455-457, 2012

PubMed Abstract: Interleukin-1 (IL-1)-family cytokines are mediators of innate and adaptive immunity. They exert proinflammatory effects by binding a primary receptor that recruits a receptor accessory protein to form a signaling-competent heterotrimeric complex. Here we present the crystal structure of IL-1β bound to its primary receptor IL-1RI and its receptor accessory protein IL-1RAcP, providing insight into how IL-1-type cytokines initiate signaling and revealing an evolutionary relationship with the fibroblast growth factor receptor family.

PubMed: 22426547
DOI: 10.1038/nsmb.2260

実験手法

X-RAY DIFFRACTION (3.1 Å)