4DE4

Crystal structure of aminoglycoside phosphotransferase APH(2")-Id/APH(2")-IVa in complex with HEPES

Replaces:  3R80

Summary for 4DE4

• Entry DOI: 10.2210/pdb4de4/pdb
• Related: 3R7Z 3R81 3R82
• Descriptor: APH(2")-Id, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID (3 entities in total)
• Functional Keywords: structural genomics, center for structural genomics of infectious diseases, csgid, niaid, national institute of allergy and infectious diseases, eukaryotic protein kinase-like fold, aminoglycoside phosphotransferase, kinase, transferase, aminoglycosides, intracellular
• Biological source: Enterococcus casseliflavus
• Total number of polymer chains: 2
• Total formula weight: 77034.69

Authors

Stogios, P.J.,Minasov, G.,Tan, K.,Nocek, B.,Evdokimova, E.,Egorova, O.,Di Leo, R.,Li, H.,Savchenko, A.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2012-01-19, release date: 2012-02-08, Last modification date: 2018-01-24)

• Primary citation: Shakya, T.,Stogios, P.J.,Waglechner, N.,Evdokimova, E.,Ejim, L.,Blanchard, J.E.,McArthur, A.G.,Savchenko, A.,Wright, G.D.; A small molecule discrimination map of the antibiotic resistance kinome.; Chem.Biol., 18:1591-1601, 2011; PubMed: 22195561; DOI: 10.1016/j.chembiol.2011.10.018

Experimental method

X-RAY DIFFRACTION (2 Å)