4DD8
ADAM-8 metalloproteinase domain with bound batimastat
Summary for 4DD8
Entry DOI | 10.2210/pdb4dd8/pdb |
Descriptor | Disintegrin and metalloproteinase domain-containing protein 8, 4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE, CALCIUM ION, ... (8 entities in total) |
Functional Keywords | batimastat, inflammation, alpha/beta motif, metalloproteinase, allergic asthma, tumorigenesis, arthritis, aberrant neural cell signaling, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P78325 |
Total number of polymer chains | 4 |
Total formula weight | 96153.62 |
Authors | Hall, T.,Shieh, H.S.,Day, J.E.,Caspers, N.,Chrencik, J.E.,Williams, J.M.,Pegg, L.E.,Pauley, A.M.,Moon, A.F.,Krahn, J.M.,Fischer, D.H.,Kiefer, J.R.,Tomasselli, A.G.,Zack, M.D. (deposition date: 2012-01-18, release date: 2012-06-06, Last modification date: 2023-09-13) |
Primary citation | Hall, T.,Shieh, H.S.,Day, J.E.,Caspers, N.,Chrencik, J.E.,Williams, J.M.,Pegg, L.E.,Pauley, A.M.,Moon, A.F.,Krahn, J.M.,Fischer, D.H.,Kiefer, J.R.,Tomasselli, A.G.,Zack, M.D. Structure of human ADAM-8 catalytic domain complexed with batimastat. Acta Crystallogr.,Sect.F, 68:616-621, 2012 Cited by PubMed: 22684055DOI: 10.1107/S1744309112015618 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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