4DD8

ADAM-8 metalloproteinase domain with bound batimastat

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
B	0004222	molecular_function	metalloendopeptidase activity
B	0006508	biological_process	proteolysis
B	0008237	molecular_function	metallopeptidase activity
C	0004222	molecular_function	metalloendopeptidase activity
C	0006508	biological_process	proteolysis
C	0008237	molecular_function	metallopeptidase activity
D	0004222	molecular_function	metalloendopeptidase activity
D	0006508	biological_process	proteolysis
D	0008237	molecular_function	metallopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE BAT A 1000

Chain	Residue
A	THR299
A	ALA365
A	GLY366
A	SER367
A	ILE368
A	ZN1002
A	CL1004
A	THR300
A	VAL301
A	GLY302
A	PHE303
A	HIS334
A	GLU335
A	HIS338
A	HIS344

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1001

Chain	Residue
A	GLU203
A	ASP286
A	CYS395
A	ASN398
A	HOH1101
A	HOH1102

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1002

Chain	Residue
A	HIS334
A	HIS338
A	HIS344
A	BAT1000

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 1003

Chain	Residue
A	ILE368
A	SER371
A	HOH1103
A	HOH1104
A	HOH1105

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1004

Chain	Residue
A	ALA304
A	HIS338
A	BAT1000

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 1005

Chain	Residue
A	ASP295
A	PHE296
A	GLY298
A	HOH1106

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE K A 1006

Chain	Residue
A	HOH1107
A	HOH1120

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K A 1007

Chain	Residue
A	ASP343
A	ASP345
A	SER380
A	HOH1109

---

site_id	AC9
Number of Residues	14
Details	BINDING SITE FOR RESIDUE BAT B 1000

Chain	Residue
B	THR299
B	THR300
B	VAL301
B	GLY302
B	HIS334
B	GLU335
B	HIS338
B	HIS344
B	ALA365
B	GLY366
B	SER367
B	ILE368
B	ZN1002
B	CL1004

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 1001

Chain	Residue
B	GLU203
B	ASP286
B	CYS395
B	ASN398
B	HOH1101

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1002

Chain	Residue
B	HIS334
B	HIS338
B	HIS344
B	BAT1000

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA B 1003

Chain	Residue
B	ILE368
B	SER371
B	HOH1102
B	HOH1103
B	HOH1104

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 1004

Chain	Residue
B	ALA304
B	GLU335
B	HIS338
B	BAT1000

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA B 1005

Chain	Residue
B	ASP295
B	PHE296
B	GLY298
B	HOH1105
B	HOH1106

---

site_id	BC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE BAT C 1000

Chain	Residue
B	PHE258
C	THR299
C	THR300
C	VAL301
C	GLY302
C	HIS334
C	GLU335
C	HIS338
C	HIS344
C	ALA365
C	GLY366
C	SER367
C	ILE368
C	ZN1002
C	CL1004
C	HOH1131

---

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 1001

Chain	Residue
C	ASN398
C	HOH1101
C	GLU203
C	ASP286
C	CYS395

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1002

Chain	Residue
C	HIS334
C	HIS338
C	HIS344
C	BAT1000

---

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA C 1003

Chain	Residue
C	ILE368
C	SER371
C	HOH1102
C	HOH1103
C	HOH1104

---

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL C 1004

Chain	Residue
C	ALA304
C	GLU335
C	HIS338
C	BAT1000
C	HOH1185

---

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA C 1005

Chain	Residue
C	ASP295
C	PHE296
C	GLY298
C	HOH1105

---

site_id	CC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE BAT D 1000

Chain	Residue
A	GLN255
A	ASP256
A	ARG257
A	HOH1125
D	THR299
D	THR300
D	VAL301
D	GLY302
D	HIS334
D	GLU335
D	HIS338
D	HIS344
D	ALA365
D	GLY366
D	SER367
D	ILE368
D	ZN1002
D	CL1004

---

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 1001

Chain	Residue
D	GLU203
D	ASP286
D	CYS395
D	ASN398
D	HOH1103
D	HOH1194

---

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 1002

Chain	Residue
D	HIS334
D	HIS338
D	HIS344
D	BAT1000

---

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA D 1003

Chain	Residue
D	ARG361
D	ILE368
D	SER371
D	HOH1104
D	HOH1105
D	HOH1106

---

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 1004

Chain	Residue
D	ALA304
D	BAT1000
D	HOH1147

---

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA D 1005

Chain	Residue
D	ASP295
D	PHE296
D	GLY298
D	HOH1107
D	HOH1108
D	HOH1109

---

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TMAHEMGHNL

Chain	Residue	Details
A	THR331-LEU340

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00276","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22684055","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	400
Details	Domain: {"description":"Peptidase M12B","evidences":[{"source":"PROSITE-ProRule","id":"PRU00276","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---