4DC0

Crystal Structure of F189W Actinorhodin Polyketide Ketoreductase with NADPH

Summary for 4DC0

• Entry DOI: 10.2210/pdb4dc0/pdb
• Related: 4DBZ 4DC1
• Descriptor: Ketoacyl reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total)
• Functional Keywords: rossmann fold, short-chain dehydrogenase/reductase, ketoreductase, oxidoreductase
• Biological source: Streptomyces coelicolor
• Total number of polymer chains: 2
• Total formula weight: 60497.63

Authors

Javidpour, P.,Tsai, S.-C. (deposition date: 2012-01-16, release date: 2013-01-16, Last modification date: 2024-02-28)

• Primary citation: Javidpour, P.,Bruegger, J.,Srithahan, S.,Korman, T.P.,Crump, M.P.,Crosby, J.,Burkart, M.D.,Tsai, S.C.; The Determinants of Activity and Specificity in Actinorhodin Type II Polyketide Ketoreductase.; Chem.Biol., 20:1225-1234, 2013; PubMed: 24035284; DOI: 10.1016/j.chembiol.2013.07.016

Experimental method

X-RAY DIFFRACTION (2.813 Å)