4DC0
Crystal Structure of F189W Actinorhodin Polyketide Ketoreductase with NADPH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008202 | biological_process | steroid metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0017000 | biological_process | antibiotic biosynthetic process |
| A | 0032787 | biological_process | monocarboxylic acid metabolic process |
| B | 0008202 | biological_process | steroid metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0017000 | biological_process | antibiotic biosynthetic process |
| B | 0032787 | biological_process | monocarboxylic acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE NDP A 301 |
| Chain | Residue |
| A | GLY13 |
| A | ASP63 |
| A | VAL64 |
| A | ASN90 |
| A | ILE142 |
| A | ALA143 |
| A | SER144 |
| A | TYR157 |
| A | LYS161 |
| A | PRO187 |
| A | GLY188 |
| A | THR15 |
| A | VAL190 |
| A | THR192 |
| A | PRO193 |
| A | MET194 |
| A | HOH401 |
| A | HOH404 |
| B | ARG51 |
| A | SER16 |
| A | GLY17 |
| A | ILE18 |
| A | ALA37 |
| A | ARG38 |
| A | GLY39 |
| A | CYS62 |
| site_id | AC2 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE NDP B 301 |
| Chain | Residue |
| B | GLY13 |
| B | THR15 |
| B | SER16 |
| B | ILE18 |
| B | ALA37 |
| B | ARG38 |
| B | GLY39 |
| B | CYS62 |
| B | ASP63 |
| B | VAL64 |
| B | ASN90 |
| B | ALA91 |
| B | GLY92 |
| B | ALA143 |
| B | SER144 |
| B | TYR157 |
| B | LYS161 |
| B | PRO187 |
| B | GLY188 |
| B | VAL190 |
| B | THR192 |
| B | PRO193 |
| B | MET194 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. StggkqgvvhAapYSASKHGVvGFTkALG |
| Chain | Residue | Details |
| A | SER144-GLY172 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10001","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 22 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15458634","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15544323","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1W4Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1X7G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1X7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XR3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15458634","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15544323","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1X7G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1X7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XR3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
